ANTI-CDC42 ANTIBODY PRODUCED IN RABBIT

Code: SAB5700705-100UL D2-231

General description

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions includ...


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General description

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20.

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 25-191 of human CDC42 (NP_001782.1).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
concentration6.89 mg/ml
formbuffered aqueous solution
Gene Informationhuman ... CDC42(998)
mol wt21
Quality Level100
shipped inwet ice
species reactivityrat, human, mouse
storage temp.−20°C
technique(s)immunohistochemistry: 1:50-1:200, immunofluorescence: 1:50-1:200, western blot: 1:500-1:2000
UniProt accession no.P60953
This product has met the following criteria to qualify for the following awards:



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